Synergistic effects of Platelet-derived growth factor-BB and Transforming growth factor-β1 on profibrogenic activities in hepatic stellate cells
O Scherner, SK Meurer, E Borkham-Kamphorst, S Sauer-Lehnen, WN Vreden, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background/Aims: Platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-β1 are important profibrogenic cytokines involved in liver fibrogenesis. They trigger the activation of hepatic stellate cells (HSC) and the synthesis of extracellular matrix (ECM) components, respectively. The pivotal role of both cytokines has been figured out by using antagonistic strategies [1]. It has been previously shown that PDGF-BB may exponentiate profibrogenic TGF-β signaling through a MAP Kinase (MAPK)-mediated modulation of Smad activity [2]. Methods: We analyzed the activation of PDGF-BB and TGF-β1 signal…
