ALR, a hepatotrophic factor is regulated by Forkhead Box A2 (HNF–3β) Transcription factor
R Dayoub, T Dobner, P Groitl, WE Thasler, C Trautwein, A Bosserhoff, HJ Schlitt, TS Weiss · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Liver regeneration is an important survival process that occurs after liver injury e.g. viral infection or hepatectomy, and involves a variety of specific transcription factors such as hepatocyte nuclear factors (HNFs). These liver transcription factor families include the HNF–3 (α, β and γ) proteins. The HNF3 family of transcription factors, also termed forkhead box (Fox) family, plays an important role in regulating hepatocellular proliferation and differentiation. Additionally, it has been shown that Foxa2 (HNF–3β) expression is induced in livers from patients with hepatocellular carcinoma HCC as well as in r…
