Not HBeAg status but HBV genotype predicts response to IFN in chronic hepatitis B
A Erhardt, A Ludwig, M Brunetto, M Popescu, F van Bömmel, H Fey, M Siemer, O Adams, D Häussinger · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background an Aims: In contrast to HBeAg-positive hepatitis B, HBeAg-negative hepatitis B is considered to be associated with a poor sustained virological response towards interferon therapy. The present study investigated the influence of HBV genotype on the presumed HBeAg-dependence of IFN response. Patients and Methods: 399 patients with chronic replicative hepatitis B infected by HBV genotype A (n=141) or HBV genotype D (n=258) were treated with standard interferon-alfa or pegylated interferon-alfa for 4–12 months. HBV genotype was determined by direct sequencing of the HBV X or S gene. 44.4% of the patients…
