Endophenotypic measures of altered inhibitory brain processes in ADHD

Objectives: Deficits in response inhibition are, amongst others, considered as candidate endophenotypes of altered prefrontal brain function in ADHD. Based on their superior time resolution, electrophysiological methods like Event-Related Potentials (ERPs) are adequate for the measurement of such endophenotypes, i.e. abnormalities in brain functions underlying psychiatric diseases like ADHD. Moreover, ERPs seem to be particular suited to measure effects of functionally relevant genetic variants directly affecting neuro-transmission systems and brain function. This principle of imaging genetics with ERPs has been…