Long Time Survival after Reduced Chemotherapy in a 15-year-old Patient with AML and Candida Krusei Sepsis and Eye Involvement
B. Bernbeck, G. Janßen, S. Winterhalter, D. T. Schneider, R. Wessalowski · TumorDiagnostik & Therapie · 2010 · Heft 04 · S. 224-225
Bibliografische Angaben
Zusammenfassung
Abstract A 15-year-old boy with AML develops a fulminant candida krusei sepsis complicated by acute blindness due to enophthalmitis and subsequent bleeding during prolonged pancytopenia after induction therapy. Despite a low dose prophylaxis with oral nystatine and i. v. amphotericin B (ampho B) three times a week (0.8 mg/kg). Under an early intensified therapy with ampho B (1.5 mg/kg/d) combined with 5-flucytosin (160 mg/kg/d) the sepsis could be controlled and visual acuity slowly improved. A vitrectomy is due to the bleeding unavoidable. Despite a therapy delay of 4 weeks and omission of two cycles of the int…
