Lipocalin 2 (LCN2) in experimental liver injury

LCN2 is a member of the lipocalin super-family with a diverse functionality, including transport of fatty acids and apoptosis induction. LCN2 expression is induced under pernicious conditions such as intoxication, infection, inflammation and other forms of cellular stress. The underlying reasons for activation however require further elucidation. Interestingly, our experimental liver injury models showed a rapid induction of well sustained LCN2 expression throughout our trials. Injured hepatocytes were identified as the main source of LCN2 production through primary liver cell isolation and immunohistochemistry.…