CareLit Fachartikel

IL-13 induces CTGF expression via a TGF-β independent mechanism in hepatic stellate cells

Y liu, C Meyer, H Shen, A Müller, MV Singer, S Dooley, HL Weng · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
1046441
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
Y liu, C Meyer, H Shen, A Müller, MV Singer, S Dooley, HL Weng
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246355

Zusammenfassung

Aims: In liver, connective tissue growth factor (CTGF) is a critical mediator of TGF-β dependent fibrogenesis, with a particular role in stimulating extracellular matrix production and hepatic stellate cell (HSC) activation. IL-13 is mainly produced by Th2 cells and is recognised as a crucial profibrotic cytokine in liver. Although the fibrotic function of IL-13 was well studied in murine models, especially in Schistosomiasis associated chronic liver disease, the underlying cellular/molecular mechanism is poorly investigated. Here, we investigate the hypothesis that IL-13 exterts its profibrogenic effects in HSC…

Schlagworte

CTGF IL-13 TGF-beta fibrosis hepatic stellate cell Zeitschrift für Gastroenterologie