Notch signaling mediates liver fibrogensis
HL Weng, Y liu, I Ilkavets, H Shen, V Zimmer, RM Bohle, C Zhu, C Xu, C Yu, C Meyer, L Ciuclan, C Stump, A Müller, T Huang, Y Li, F Lammert, MV Singer, PR Mertens, S Dooley · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Notch signaling is crucial in the development of metazoans, determining cell fate, and is directly linked to multiple human disorders, including Alagille syndrome in liver. We hypothesized that the Notch signaling pathway participates in liver fibrogenesis. Methods: Notch receptor and ligand expression in human and mouse livers were evaluated by immunohistochemistry and western blot. The effect of Notch signaling inhibitor was examined in hepatic stellate cells (HSCs). Results: In 2-weeks bile duct ligated mice, expression of Notch receptors (Notch-2, -3 and -4) and ligands (Jagged-1 and Jagge…
