Panobinostat induces oncosuppressor hsa-let-7b leading to downregulation of its downstream targets in HCC cells

Background Discovery of miRNAs represents a new step to clarify mechanisms of intracellular regulation of factors involved in cellular processes. Hsa-let-7b is an oncosuppressor miRNA that down-regulates the expression of proteins identified as regulators of proliferation and embryonic development and is overexpressed in several tumor types, giving them high proliferative properties. Little is known about the expression of miRNAs and their downstream targets in HCC. We clarify here that panobinostat (LBH589; Novartis Oncology), a pan-deacetylase inhibitor, is able to regulate miR expression and its targets in HC…