FOXO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by Resveratrol

Resveratrol, a polyphenol derived from grapes, exerts important effects on glucose and lipid metabolism, yet detailed mechanisms mediating these effects remain unknown. The liver plays a central role in energy homeostasis and glucokinase (GK) is a key enzyme involved in glucose utilization. Resveratrol activates sirtuin 1 (SIRT1) which promotes deacetylation of the forkhead transcription factor FoxO1. Previously, we reported that FoxO1 can suppress and that HNF-4 can stimulate GK expression in the liver. Here, we examined the role of FoxO1 and HNF-4 in mediating resveratrol effects on liver GK expression. Resver…