Chronic alcohol feeding potentiates the formation of mutagenic etheno-adducts in obese Zucker rats via induction of cytochrome P450 2E1
E Patsenker, M Ledermann, G Millonig, S Mueller, H Saegesser, V Schneider, HK Seitz, F Stickel · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chronic alcohol intake may promote liver fibrosis and hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD). Synergistic effects of insulin resistance and alcohol on cytochrome P450 2E1 (CYP2E1) induction, fibrogenesis and hepatocarcinogenesis are implicated. Mutagenic etheno adducts binding to adenosin (EdA) generated via CYP2E1 have been suggested as triggers of hepatocarcinogenesis. Methods: Obese Zucker rats and lean littermates (4 groups, n=10 each) were pair-fed Lieber-De Carli liquid diets containing 36% of total calories as ethanol or carbohydrates for 12 weeks. Liver histolog…
