CareLit Fachartikel
Expression changes of DOR and other thyroid hormone effector genes in rat liver during acute-phase response
IA Malik, N Naz, F Moriconi, F Moriconi, B Baumgartner, G Ramadori · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1046462
CareLit-ID
Jahr
2010
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Zusammenfassung
Acute phase is characterized not only by increased serum levels of acute phase reactants such as the well studied IL-1β, IL-6 or TNFα, but also by reduced thyroid hormone levels. The aim of this study was to analyze the expression of key members of the thyroid hormone signalling pathway such as TRα1, TRα2, TRβ1, NCoR-1 and the newly identified thyroid hormone receptor cofactor DOR/TP53INP2 during acute phase response (APR) in rat liver. In the present study, turpentine oil (TO) was injected into the hind limb muscle of rats to stimulate an APR. By means of immunohistology, abundant DOR expression in the nuclei o…
Schlagworte
DOR
Liver
Thyroid hormone
acute-phase
cytokines
Zeitschrift für Gastroenterologie
