Wnt proteins differenzially regulate macrophage functions in the context of M. tuberculosis infection

Wnt proteins are secreted palmitoylated glycoproteins with multiple functions in cell proliferation, migration as well as tissue organization. They are best known for their role in embryonic development and tissue homeostasis. We have recently identified Wnt5a and Frizzled5 to be functionally involved in the regulation of the Th1 cytokine response indicating a role in antimicrobial defense (Blumenthal et al, Blood 2006). In a systematic screen of Wnt/Fzd homologs in murine bone marrow derived macrophages, we have now identified Frizzled1 to be upregulated in response to mycobacteria and conserved bacterial struc…