CareLit Fachartikel
Influence of melatonin on secretion rhythms and signal-transduction processes in the pancreatic β-cell: melatonin–insulin interactions
E Peschke · Klinische Neurophysiologie · 2010 · Heft 03
Dokument
1046645
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Recently, many investigations on the functional interactions between the pineal gland and glucose metabolism have been collected: (i) Melatonin influences insulin secretion and, in general, decreases insulin secretion both in vivo and in vitro. Moreover, the effects of melatonin on insulin secretion have been shown to be receptor mediated. Expression of the melatonin receptor MT1 and, more recently, that of the MT2 receptor have been detected in the pancreas. (ii) It has also been determined that the effects on insulin secretion are mediated through specific, high-affinity pertussis-toxin-sensitive Gi-protein-co…
Schlagworte
Alloxan
Arylalkylamine N-Acetyltransferase
Adenosine Monophosphate
Guanosine Monophosphate
Reactive Oxygen Species
Alkylating Agents
Diabetes Mellitus
Association
Observation
Adenosine
Lead
After
Klinische Neurophysiologie
