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Impaired motor cortex plasticity in patients with Noonan-Syndrome

F Mainberger, M Zenker, N Jung, I Delvendahl, A Brandt, L Freudenberg, V Mall · Klinische Neurophysiologie · 2010 · Heft 03

Dokument
1046653
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Jahr
2010
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
F Mainberger, M Zenker, N Jung, I Delvendahl, A Brandt, L Freudenberg, V Mall
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1250935

Zusammenfassung

Introduction: Noonan Syndrome (NS) is caused by a mutation of genes, leading to hyperactivation of the Ras-pathway. Recent in vitro studies demonstrated a Long Term Potentiation (LTP) impairment caused by RAS-pathway hyperactivity. Methods: In this study 8 patients with Noonan-Syndrome (mean 26.25±11.25 years, 5 female, 3 male) and an age and gender matched control group (mean 25.13±3.44 years, 5 female, 3 male) were investigated using paired associated stimulation (PAS). Changes in MEP amplitude were investigated before, immediately after (post 1), 30 (post2) and 60 (post 3) minutes after PAS. Results: We demon…

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