Human motor cortex excitability can be modulated using combined tRNS and pharmacological intervention

Introduction: Recent studies have demonstrated that a 10min application of transcranial random noise stimulation (tRNS) over the primary motor cortex (M1) induces persistent excitability increases lasting over 60mins. It is not yet known which ion channels or receptors are potentiated in order to achieve these effects. Materials and Methods: To characterise the mechanisms of tRNS induced cortical modulations, a number of CNS active agents were examined in combination with tRN stimulation. Monophasic single-pulse transcranial magnetic stimulation (TMS) was used to measure levels of cortical excitability before an…