Efficacy profile of daptomycin for the treatment of invasive as compared to non-invasive pulmonary infections with S. pneumoniae

Background: Daptomycin is a novel lipopeptide antibiotic with excellent activity against Gram-positive bacterial pathogens, but its therapeutic value for the treatment of invasive pneumococcal disease as compared to pneumococcal pneumonia is incompletely defined. We investigated the efficacy of daptomycin in two models of S. pneumoniae-induced lung infection, i.e., pneumococcal pneumonia or septic pneumococcal disease. Methods: Mice were infected with bioluminescent, invasive serotype 2 or less virulent serotype 19 S. pneumoniae, followed by semi-therapeutic or therapeutic daptomycin or ceftriaxone treatment. Re…