Endoscopic therapy of submucosal invasive colorectal carcinomas – assessment of endoscopical and histopathological criteria predicting success or failure of treatment

Aims: Due to the potential risk of remission and metastasis, oncological resection is currently recommended after endoscopic resection of submucosal invasive colorectal cancer (pT1) if a “high-risk“ situation (i.e. venous or lymphatic vessel infiltration, poor tumor differentiation or R1/Rx-resection) is present. However, there are sparse data on the long-term outcome of patients with low-risk cancers compared with those with high-risk cancers in whom surgery was not performed. Patients and methods: Between 1974 and 2002, a total of 318 cases of solely endoscopically treated pT1-cancers were registered in the De…