Quantitative Imaging of Transmural Vasa Vasorum Distribution in Aortas of ApoE-/-/LDL-/- double knockout Mice using Nano-CT
M Kampschulte, A Brinkmann, P Stieger, DG Sedding, C Dierkes, RM Bohle, EL Ritman, A Langheinrich · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: To evaluate the distribution of vasa vasorum (VV) in advanced atherosclerotic lesions (calcified, fibrotic or hemorrhaged) in the aortic wall of apoE-/-/LDL-/- mice in relation to aortic luminal and plaque cross-sectional surface area using high-resolution nano-CT Methode: Aortas from male apoE-/-/LDL-/- mice (n=7) at the age of 80 weeks were infused in situ with contrast agent, harvested for scanning with Nano-CT (NCT) and followed by sectioning for histology. The spatial distribution of Vasa Vasorum [number and surface/cross-section (mm2)] was compared to aortic luminal cross-sectional area in the ascen…