Prevalence and prognostic significance of chromosome 21 amplifications in children with relapsed acute lymphoblastic leukemia: the ALL-REZ BFM study group
S Krentz, J Hof, E Klopocki, G Körner, F Troitier, C Steinhoff, K Seeger, S Mundlos, C Hagemeier, A von Stackelberg, G Henze, C Eckert, R Kirschner-Schwabe · Klinische Pädiatrie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Survival after relapse of childhood ALL is currently predicted from clinical factors; however, the underlying molecular determinants are poorly understood. To identify chromosomal alterations associated with prognosis, we screened 223 patients with first relapse of B-cell precursor ALL by multiplex ligation-dependent probe amplification (MLPA). Gains of chromosome 21 (chr21) were the most frequent alterations (41%) that were further classified into 3 groups: gain of chr21 (+21, 15%), gain of chr21 and a pattern of additional gains consistent with high hyperdiploidy (+21/HHD, 21%) as well as intrachromosomal ampl…
