The homeobox transcription factor HoxC9, a key regulator of development, suppresses tumourigenicity of neuroblastoma
H Kocak, S Ackermann, B Hero, Y Kahlert, J Theissen, V Ehemann, F Westermann, M Odenthal, A Oberthuer, F Berthold, M Fischer · Klinische Pädiatrie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: This study aimed at elucidating the role of HoxC9 in NB (neuroblastoma) spontaneous regression and differentiation. Methods: HOXC9 expression levels from 476 NB patients were calculated using microarray technology. HOXC9 gene silencing in NB was investigated by aCGH and methylation analysis. The molecular function of HoxC9 was investigated using a Tet-inducible expression system. The effect of HoxC9 on in vivo tumourigenicity was analysed in NB xenograft models. Results: HOXC9 down-regulation is significantly associated with unfavourable prognostic markers, unfavourable gene expression-based classifi…
