Antiviral treatment with peginterferon plus Ribavirin reduces serum leptin levels in patients with chronic hepatitis C
C Putz-Bankuti, T Stojakovic, H Scharnagl, B Bauer, H Pock, M Trauner, RE Stauber · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aims: Elevated triglyceride levels during interferon treatment of chronic hepatitis C (CHC) have been repeatedly demonstrated but the mechanism for this change is still unknown. The aims of our prospective study were to investigate the effects of antiviral treatment with peginterferon (pegIFN) plus ribavirin on serum adipokine levels, insulin resistance and lipid status in patients with CHC. Methods: Fifty-three treatment-naïve patients (35 males and 18 females; genotype (GT) 1=38, GT2=8, GT3=6, GT4=1) were treated with pegIFN alpha 2a (180µg weekly; n=26) or alpha 2b (1.5µg/kg weekly; n=27) plus…
