The prognostic value of cell proliferation in colorectal adenomas and carcinomas

Introduction: Colorectal tumorigenesis is a multistep process that begins with the abrogation of normal controls of colorectal mucosa. Aim: Examination of the shift through the adenoma-carcinoma progression sequence of human colon and rectum in context with the expression difference of proliferating cell nuclear antigen (PCNA) between adenoma-carcinoma and adjacent mucosa. Materials and Methods: 178 patients with colorectal polyp-adenoma and/or colorectal carcinoma underwent endoscopic polypectomy or surgical resection. The PCNA expression was examined in 28 non-neoplastic epithelial polyps, 82 neoplastic adenom…