1H-MRS profile in MRI positive versus MRI negative patients with temporal lobe epilepsy
M Dölken, H Stefan, T Struffert, T Engelhorn, GM Richter, O Ganslandt, A Doerfler, T Hammen · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: The objective of this study was to quantitate and compare ipsilateral total N-acetyl aspartate (tNAA), creatine (Cr), choline (Cho), myo-inositol (m-Ins) and glutamate plus glutamine (Glx) levels in the hippocampi of patients with temporal lobe epilepsy (TLE) with and without MRI evidence for mesial temporal sclerosis (MRI positive/negative). Methode: 23 age matched healthy controls and 26 consecutive patients with unilateral TLE based on intensive 24 hours Video-EEG (9 MRI negative, 17 with unilateral hippocampal sclerosis in MRI – MRI positive) were investigated with Proton Magnetic Resonance Spectrosco…