Association of FTO variants with BMI, fat mass and waist in the isolated population of Sorbs in Germany
A Tönjes, E Zeggini, P Kovacs, Y Böttcher, D Schleinitz, AP Morris, B Enigk, NW Rayner, K Hoffmann, D Teupser, J Thiery, K Krohn, MI McCarthy, M Stumvoll · Diabetologie und Stoffwechsel · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
The association between common variants in the FTO gene with weight, adiposity, body mass index (BMI) and risk of obesity has now been widely-replicated in samples of European origin. Though the causal variant has yet to be identified, it most likely maps within a 47kb region of intron 1 of FTO. We evaluated the relationships between FTO variants and BMI and related traits in the Sorbic population, an isolate of Slavonic origin resident in Deutschland. In a sample of 929 Sorbs, we could replicate the previously-reported associations of intron 1 SNPs with BMI (e.g. p=8.5×10–5 for rs8050136). However, using genome…
