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The genetic variation in the IDE (insulin degrading enzyme) gene is associated with impaired insulin metabolism and increased risk of type 2 diabetes

N Rudovich, O Pivovarova, E Fisher, M Osterhof, M Moehlig, J Spranger, P Slominsky, H Boeing, M Schulze, AFH Pfeiffer · Diabetologie und Stoffwechsel · 2008 · Heft 04

Dokument
1047175
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
N Rudovich, O Pivovarova, E Fisher, M Osterhof, M Moehlig, J Spranger, P Slominsky, H Boeing, M Schulze, AFH Pfeiffer
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-18 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2008-1076445

Zusammenfassung

Aims: Evidence for linkage of type 2 diabetes to a region on chromosome 10q23-q25 has been provided in several populations. Among genes in this region is IDE encoding insulin degrading enzyme which serve as a major enzyme responsible for insulin proteolysis. IDE knockout mice show a diabetic phenotype with hyperinsulinemia. Thus, the aim of the present study was to examine the genetic associations between IDE SNPs, insulin metabolism and the risk for T2DM in the Metabolic Syndrome Berlin-Potsdam (MESYBEPO) and European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) study populations.…

Schlagworte

Association Population Berlin Diabetologie und Stoffwechsel