New technics of surfactant instillation therapy during nasal-CPAP in premature infants

Lung disease, especially hyaline membrane disease, causes significant morbidity in preterm newborns. The pathophysiology of this disorder has been well characterized. Due to the lack of surfactant in the immature lung, lung compliance is low and also functional residual capacity. This increases intrapulmonal deadspace and a ventilation- perfusion mismatch, causing hypoxaemia and hypercarbonaemia. As the pathophysiology is based on the lack of surfactant, surfactant replacement therapy is evident and well established as rescue or prevention treatment in preterm infants suffering from infant respiratory distress s…