Different cytokine patterns in alcoholic cirrhosis, HCV-related cirrhosis and primary biliary cirrhosis

Introduction/aim: The uncoordinated activation of immune system plays a central role in the pathogenesis of chronic liver diseases (CLD) irrespectively of the etiology. We aimed to investigate cytokine patterns in three major types of cirrhosis. Patients and methods: The sera of 36 patients with alcoholic cirrhosis, 14 with HCV-related cirrhosis and 35 with BPC along with those of 26 healthy controls were tested for 9 cytokines (IL-1a; IL-1b; IL-2; IL-4; IL-6; IL-8; IL-10; IFN-gamma; TNF-alpha) and 3 growth factors (EGF; MCP-1; VEGF) with a Randox Biochip protein array. We also measured 21 routine chemical and h…