Altered surface expression of inhibitory KIR2DL3 and activating CD160, NKG2D receptors on NK and cytotoxic T cells in chronic HCV hepatitis
G Pár, L Szereday, T Berki, A Miseta, G Hegedûs, J Szekeres, G Mózsik, B Hunyady, Á Vincze, A Pár · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Natural killer cell activity depends on balance between signals by killer activating (KAR) and inhibitory (KIR) receptors. In HCV infection upregulated expression of inhibitory NKG2A and downregulation of activating NKp30, NKp46 receptors have been described. Here, we analyzed whether the known impaired activity of NK cells is associated with dysregulated expression of further inhibitory (KIR2DL3, ILT-2, KIR3DL1) and activatory (CD160, NKG2D, NKG2C) receptors. Since regulatory T cells (T reg) via secreting TGFbeta can downregulate different KARs, correlation between percentage of T reg cells, plasma TGFb l…
