CareLit Fachartikel
Effect of hydrochloric acid and alcohol on duodenal chemosensitivity: Duodenal acid exposure paradoxically reduces chemosensitivity
M Führer, J Hammer · Zeitschrift für Gastroenterologie · 2008 · Heft 06
Dokument
1047393
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Zusammenfassung
Introduction: Chemosensitivity for capsaicin that is independent from mechanosensitivity has recently been demonstrated in the duodenum. Capsaicin stimulates the polymodal vanilloid receptor of type 1 (VR1) on nociceptive afferent neurons and induces pain and non-painful sensation. Other stimulators of VR1 include heat, acid, or alcohol. Aims: The aims of the study were to evaluate the effects of duodenal acid and alcohol exposure on chemo- and mechanosensitivity. Methods: N=17 healthy subjects swallowed a tube assembly with an infusion site and a barostat in the mid-duodenum for pressure controlled random diste…
Schlagworte
Capsaicin
After
Hydrochloric Acid
Compliance
Lead
Zeitschrift für Gastroenterologie
