Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis
N Azoitei, GV Pusapati, A Kleger, C Brunner, F Genze, C Ruhland, G Adler, T Seufferlein · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: The protein kinase D (PKD) family of serine/threonine kinases belongs to the subfamily of the calcium-calmodulin kinase-like superfamily that comprises of PKD1/protein kinase Cµ, PKD2, and PKD3/protein kinase Cv. PKD isoforms have been implicated in various biological processes, including cell proliferation, regulation of Golgi function and apoptosis. We found PKD2 to be highly expressed in pancreatic cancer as well as in the tumor associated endothelia. Aim: The aim of this study was to investigate the role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis. Approach: The role…
