Opposing prognostic impact of the heme oxygenase-1 promoter polymorphism in complete resected esophageal cancer

Purpose: Germ line polymorphism represent stable genetic markers that are unbiased by the genomic instability occurring in tumor tissue DNA. The basal transcription of heme oxygenase-1 regulation is dependent upon a GTn repeat polymorphism in the promoter of the heme oxygenase-1 gene. Here, we evaluated the prognostic impact of the GTn polymorphism in complete resected esophageal cancer patients who neither received neoadjuvant or adjuvant therapy. Patients and methods: Genomic DNA was extracted from peripheral blood leucocytes of 297 patients. To determine the number of the GTn repeats DNA was amplified by PCR…