The common G/C variant in precursor miR-146a in the genetic predisposition to cholangiocarcinoma
V Zimmer, F Mihalache, A Höblinger, F Grünhage, M Krawczyk, B Diaconu, BC Gärtner, T Sauerbruch, M Acalovschi, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and Aim: Micro RNAs (miRNAs) are small, non-coding RNA species considered to fine-tune basic cellular functions by modulation of target gene translation and/or mRNA stability. A common G/C polymorphism (rs2910164) in the precursor (pre-) miR-146a gene engaged in NF-κB signalling and apoptosis pathways has previously been reported to increase the genetic risk of hepatocellular carcinoma by increased G-allelic production of mature miR-146a (Xu, Carcinogenesis 2008; Jazdzewksi, Cell Cycle 2009). Thus, in this study we investigated rs2910164 as a potential genetic susceptibility factor in a large European…
