Functions of C-Jun terminal kinases 1 and 2 in pancreatic cancer cells
X Tian, A Winkler, S Paschke, G Chen, S Zhou, M Bachem, D Henne-Bruns, M Kornmann · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and Aims: The c-Jun N-terminal protein kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family. JNKs have been recognized as critical regulators of several important physiological functions like cell proliferation, apoptosis, DNA repair and metabolism. However, the role of JNKs in human cancers is controversial. The aim of this study was to elucidate possible functions of JNK-1 and -2 in human pancreatic cancer. Methods: Expression and activity of JNK1 and 2 were determined by immunoblot and activity assay in 7 cultured human pancreatic cancer cell lines. The effects of the JN…
