CareLit Fachartikel
Induction of HEME Oxygenase 1 reduces inflammation and fibrosis in a mouse model of chronic hepatitis
R Barikbin, D Schwinge, C Schramm, G Tiegs, G Sass · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1047973
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Heme oxygenase 1 (HO-1) is an essential enzyme in heme catabolism and has been shown to protect from acute inflammation induced liver damage. We now investigated effects of HO-1 induction in a mouse model of chronic hepatitis (Mdr2 knockout; Mdr2ko; FVB.129P2-Abcb4tm1Bor), characterized by fibrosis and progression to hepatocellular carcinoma (HCC). Methods: 5 or 12 weeks old Mdr2ko mice were treated with the HO-1 inducer cobalt protoporphyrin IX (CoPP) twice a week for 7 consecutive weeks. Liver damage was monitored by alanin aminotranferase (ALT) levels. Leukocyte infiltrations were visualized by H&E stai…
Schlagworte
AFP
CoPP
HCC
HO-1
MDR2
fibrosis
inflammation
Zeitschrift für Gastroenterologie
