IL-15 mRNA expression is associated with liver cirrhosis
R Vogt, P Godoy, G Campos, R Stöber, JG Hengstler, HJ Schlitt, M Melter, TS Weiss · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Backgroun d: Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. Further it was reported that IL-15 is expressed in hepatocytes and supports liver regeneration. However, IL-15's roles in the liver are largely unknown. The aim of our study was to analyze the IL-15 expression in a mouse model of liver fibrosis and IL-15-/- KO mouse and in human liver tissues. Methods: Total RNA was isolated from mouse and human liver tissue samples and mRNA- expression was analyzed by RT- PCR. Human liver biopsies were analyzed by a pathologi…
