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Humanized tumor mice–a new cutting-edge model to study immune responses in advanced cancer therapy

A Krömer, G Brockhoff, A Wege · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1047984
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Krömer, G Brockhoff, A Wege
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269565

Zusammenfassung

Introduction: Antibody-based cancer therapy (e.g Herceptin) represents a novel and promising therapeutic option for advanced oncologic disease. Nevertheless, due to lack of appropriate in-vivo models, the impact of the human immune system on antibody based cancer therapy still remains poorly understood. This constitutes a major issue in oncology that clearly requires further investigation. Methods: For the generation of humanized tumor mice, NOD/scid/IL-2 receptor-γ chain-KO mice were irradiated (1Gy) and intrahepatically co-transplanted with 3×106 Her2SK-BR-3 Her2+ human breast cancer cells and CD34+ stem cells…

Schlagworte

Her2 NK cells antibody-based cancer therapy hepatic cancer humanized mice Zeitschrift für Gastroenterologie