The hop chalcone xanthohumol beneficially affects hepatocellular lipid metabolism

Since ancient times, hop (Humulus lupulus L.) has been used in folkloric medicine. Xanthohumol (XN) is the main flavonoid found in hop inflorescences, and dietary intake is up to 100mg/day, largely depending on beer consumption. Furthermore, XN-containing dietary supplements are marketed, and we recently demonstrated that XN exhibits anti-fibrogenic effects on hepatic stellate cells and anti-tumorigenic effects on HCC cells, respectively. Little is known about the effects of XN on (hepatic) metabolisms. The aim of this study was to analyze the effects of XN on hepatocellular lipid metabolism. Methods and Results…