CareLit Fachartikel

MDR2-/- Mice as Model for Hepatic Osteodystrophy

A Schmid, Y Lau, S Ehnert, S Dooley, U Stöckle, B Wildemann, AK Nussler · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1047987
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Schmid, Y Lau, S Ehnert, S Dooley, U Stöckle, B Wildemann, AK Nussler
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269595

Zusammenfassung

People suffering from chronic liver diseases often have an increased incidence of bone fractures caused by reduced bone mineralization. Mice deficient in the ABCb4 transporter (MDR2-/-) suffer from chronic liver disease similar to PBS and PSC. Aim of this study was to analyze changes in bone mineral density and architecture of MDR2-/- mice over time and to identify possible regulatory mechanisms. MDR2-/- mice and wildtype controls were sacrificed 5, 7, 9, 11, 13, 15, 20, 30 and 44 weeks after birth (N=4). Progression of liver damage, evaluated by histological staining of the liver (H&E, Masson Goldner Trichrome)…

Schlagworte

Hepatic osteodystrophy MDR2-/- mice bone mineral density Zeitschrift für Gastroenterologie