Investigation of early proteomic changes in liver affected by non-alcoholic steatohepatitis

The increasing number of obesity in western society is a major cause for higher incidence of metabolic aberrations as insulin resistance and non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most severe form of NAFLD, characterized by liver steatosis and inflammation leading to a significant deterioration in liver function, possibly culminating in liver cirrhosis. However, the exact mechanism of NASH development is still unclear.An established mouse model system for NASH is used to assess the early changes in hepatic protein regulation. Wild-type mice are fed with a high-fat…