Role of exo- and endogeneous mesenchymal stem cells in liver ischemia reperfusion injury

Introduction: Mesenchymal stem cells (MSC) are one of the most promising cell populations for cell based immune therapy in solid organ transplantation. A transplanted organ is up against immune response of the recipient but also stress and tissue damage caused by ischemia and reperfusion. Besides their immuno suppressive function, MSC exert also beneficial influence on tissue regeneration. Methods: Influence of MSC were investigated in a murine heterotopic heart tranplantation model and a ischemia/reperfusion injury (IRI) liver damage model. We used two different types of MSC. On the one hand exogenous MSC, isol…