A novel non-MHC-I restricted CTL effector function mediated by TNF and XIAP
K Gärtner, D Stabenow, M Odenthal, B Arnold, G Hämmerling, U Protzer, HP Dienes, C Kurts, M Krönke, PA Knolle · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Viruses can escape cytotoxic T cell (CTL) immunity by avoiding presentation of viral components via the endogenous MHC class I antigen-presentation pathway in infected cells. Cross-priming of viral antigens circumvents such immune escape mechainsms by allowing non-infected dendritic cells to activate virus-specific CTLs. However, activated CTLs remain ineffective as long as viral immune escape is functional in infected target cells and antigen is not presented on MHC class I molecules. Here we show that cross-presentation of antigen from virus-infected hepatocytes by liver sinusoidal endothelial cells stimulates…
