CareLit Fachartikel

The association of 2B4 up-regulation and SAP down-regulation indicates exhaustion of virus-specific CD8+ T cells

V Schlaphoff, S Lunemann, SV Pothakamuri, J Jaroszewicz, J Grabowski, S Pischke, FA Helfritz, MP Manns, M Cornberg, H Wedemeyer · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1047997
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
V Schlaphoff, S Lunemann, SV Pothakamuri, J Jaroszewicz, J Grabowski, S Pischke, FA Helfritz, MP Manns, M Cornberg, H Wedemeyer
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269695

Zusammenfassung

The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed by CD8+ T cells. The aim of this study was to analyze the role of 2B4 as an additional costimulatory receptor regulating CD8+ T cell function and in particular to investigate its implication for exhaustion of hepatitis C virus (HCV)-specific CD8+ T cells during persistent infection.We demonstrate that (i) 2B4 is expressed on virus-specific CD8+ T cells during acut…

Schlagworte

2B4 CD8+ T cells PD-1 hepatitis C Zeitschrift für Gastroenterologie