Protection from allergy by a novel synthetic lipopeptide

Growing up on a farm provides protection from developing allergies. One explanation for this observation is given by the „hygiene hypothesis“, which states that the prevalence of allergies is increasing due to reduced risk of infection. In a mouse model of allergy and asthma, we have shown previously that extracts of cowshed dust extract (CDE) from traditional farms protect mice from allergy. Moreover, our study revealed that LPS was not responsible for the effect of CDE. It was also shown that prolonged exposure of bone-marrow derived dendritic cells (BMDCs) to CDE reduced their capacity to induce allergy when…