The contribution of eye movements to discriminate Parkin-linked and idiopathic Parkinson's disease

Objective: To investigate, if cerebral hemispheric eye movement disorders help to differentiate between Parkinsonian patients with Parkin mutations and those with idiopathic Parkinson's disease (PD). Background: Parkin gene mutations are the most common cause of early-onset parkinsonism. Patients with Parkin mutations may be clinically indistinguishable from patients with idiopathic Parkinson's disease (PD). At present, there is no specific clinical feature that clearly distinguishes this monogenic form from idiopathic PD. Eye movement disorders can help to differentiate parkinsonian syndromes, but have never be…