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Genome-wide associations of genetic variation with minimal residual disease in ETV6-RUNX1-positive childhood acute lymphoblastic leukemia

T Bartram, E Ellinghaus, R Panzer-Grümayer, G Cario, A Teigler-Schlegel, A Nebel, B Meissner, P Breithaupt, A Schrauder, P Nürnberg, M Zimmermann, S Schreiber, M Schrappe, A Franke, M Stanulla · Klinische Pädiatrie · 2011 · Heft 05

Dokument
1048376
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
T Bartram, E Ellinghaus, R Panzer-Grümayer, G Cario, A Teigler-Schlegel, A Nebel, B Meissner, P Breithaupt, A Schrauder, P Nürnberg, M Zimmermann, S Schreiber, M Schrappe, A Franke, M Stanulla
Ausgabe
Heft 05 / 2011
Seiten
–
Erschienen: 2011-05-05 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1277065

Zusammenfassung

Aim: To assess the association of host genetic variation and early response to treatment as measured by minimal residual disease (MRD) in ETV6-RUNX1 fusion gene-positive childhood acute lymphoblastic leukemia (ALL) treated on protocol ALL-BFM 2000. Methods: Genome-wide association analysis of 355,750 SNPs was performed in 311 patients demonstrating clearance of leukemic blasts from the bone marrow beyond measureable levels after induction therapy (

Schlagworte

Klinische Pädiatrie