D-L1 blockade effectively restores strong graft-versus-leukemia effects without graft- versus-host-disease after delayed adoptive transfer of T cell receptor gene-engineered allog…
W Koestner, M Hapke, J Herbst, C Klein, K Welte, J Fruehauf, A Flatley, DA Vignali, M Hardtke-Wolenski, E Jaeckel, BR Blazar, MG Sauer · Klinische Pädiatrie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Adoptive transfer (AT) of T cells forced to express tumor-reactive T cell receptor (TCR) genes is an attractive strategy to direct autologous T cell immunity against tumor-associated antigens (TAAs). However, clinical effectiveness has been hampered by limited in vivo persistence. We investigated whether the use of MHC-mismatched T cells would prolong the in vivo persistence of tumor-reactive TCR gene expressing T cells by continuous antigen-driven proliferation via the endogenous potentially alloreactive receptor. Donor-derived CD8+ T cells engineered to express a TCR against a leukemia-associated antigen media…
