Potential mechanism of rosiglitazone induced myocellular insulin sensitivity-effects of rosiglitazone on 11β-hydroxysteroid dehydrogenase type 1 expression in skeletal muscle
K Mai, S Meinus, A Assmann, T Bobbert, J Andres, K Biedasek, C Maser-Gluth, S Wudy, M Hartmann, A Pfeiffer, S Diederich, J Spranger · Diabetologie und Stoffwechsel · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: PPARg agonists like rosiglitazone (R) increase insulin sensitivity in skeletal muscle, although the underlying mechanism is not entirely clear yet. The detrimental metabolic effects of glucocorticoids and 11β-HSD1 in human adipose tissue are well established, while data on myocellular 11β-HSD1 in humans are currently sparse. We aimed to investigate whether PPARg agonists modulate activity and expression of 11β-HSD1 in skeletal muscle in-vitro. In addition, we performed an 8-week human trial to confirm our findings in humans. Methods: 11β-HSD1 mRNA expression was measured in cultured C2C12 cells after incub…
