Genetic polymorphysms in HCV infection: Both IL28B and IL10R -1087 variants are protective and predict sustained virological response. A nationwide multicentric study
A Pár, P Kisfali, I Tornai, F Szalay, E Fráter, M Papp, G Lengyel, J Fehér, M Varga, J Gervain, J Schuller, Z Nemes, Z Péterfi, A Tusnádi, B Hunyady, A Haragh, Z Szinku, Á Vincze, G Pár, B Melegh · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Earlier we have found that not only IL28B but IL10R -1087 gene polymorphysms may also play a role in HCV infection, and we suggested further studies with higher number of patients to support and prove this statement. Thus, a multicentric study was carried out, in which the allele frequencies of these two genetic variants were compared to that of healthy controls, and the relationship between the polymorphysms and the response to PEG-IFN + ribavirin treatment were examined in HCV infection. Patients: seven hundred and seven chronic HCV genotype 1 patients (336 men, 371 female) (18–82 years, mean 53.4±…
