Inhibition of PDGFRβ in colorectal cancer cells leads to decreased proliferation and G2 cell cycle arrest

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the western world and growth factors and their receptors play a significant role in the regulation of CRC growth, angiogenesis, and metastasis. The platelet-derived growth factor receptor (PDGFR) has attracted increasing attention as potential target of anti-tumor therapy in CRC. In the present study the influence of the α- and β-subunit of the PDGFR (PDGFRα, -β) was investigated in different CRC cell lines. PDGFRα expression was not observed in all cell lines tested, however, varying expression levels of PDGFRβ could be detected bot…